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Cet ouvrage reproduit les vingt-neuf chroniques parues de fin 1991 à 2002, accompagnées de commentaires qui les résultent dans leur contexte et examinent si, avec le recul, elles se révèlent ou non pertinentes.C'est donc un document qui fournit un éclairage sur ces dix années au cours desquelles la séquence de l'ADN humain, pur fantasme à usage politique au début, est devenue une réalité scientifique- sans pour antant, bien sûr, répondre à toutes les questions que pose la biologie.

Human genetics

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How tiny variations in our personal DNA can determine how we look, how we behave, how we get sick, and how we get well.News stories report almost daily on the remarkable progress scientists are making in unraveling the genetic basis of disease and behavior. Meanwhile, new technologies are rapidly reducing the cost of reading someone's personal DNA (all six billion letters of it). Within the next ten years, hospitals may present parents with their newborn's complete DNA code along with her footprints and APGAR score. In Genetic Twists of Fate, distinguished geneticists Stanley Fields and Mark Johnston help us make sense of the genetic revolution that is upon us.Fields and Johnston tell real life stories that hinge on the inheritance of one tiny change rather than another in an individual's DNA: a mother wrongly accused of poisoning her young son when the true killer was a genetic disorder; the screen siren who could no longer remember her lines because of Alzheimer's disease; and the president who was treated with rat poison to prevent another heart attack. In an engaging and accessible style, Fields and Johnston explain what our personal DNA code is, how a few differences in its long list of DNA letters makes each of us unique, and how that code influences our appearance, our behavior, and our risk for such common diseases as diabetes or cancer.

Medical genetics --- Human genetics --- BIOMEDICAL SCIENCES/General --- Genetics (non-medical)

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Medical genetics --- Human genetics --- Genetic disorders --- Genetics, Medical. --- Pathology

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Large-scale study of populations may contribute significantly to science’s understanding of the complex multi-factorial basis of disease and to improvements in prevention, detection, diagnosis, treatment and cure. This book summarises the proceedings of a conference on human genetic research databases.  It examines what they are and provides a number of examples. It looks at how they have been established, governed, and funded. And it looks at how they are managed and commercialised, exploring what the policy implications are for governments. 

Chromosome Mapping. --- Human genetics -- Databases -- Law and legislation -- Congresses. --- Human genetics -- Databases -- Moral and ethical aspects -- Congresses. --- Human genetics. --- Linkage (Genetics). --- Human genetics --- Databases, Factual --- Databases as Topic --- Information Storage and Retrieval --- Information Systems --- Medical Informatics Applications --- Information Science --- Medical Informatics --- Databases, Genetic --- Biology --- Health & Biological Sciences --- Genetics --- Moral and ethical aspects --- Databases --- Law and legislation --- Heredity, Human --- Human biology --- Physical anthropology

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Matrix metalloproteinases (MMPs) are a family of proteolytic zinc-containing enzymes involved in physiological as well as in pathological processes in the human organism. MMPs play a key role in the remodeling of the extracellular matrix. Such a process may occur because of tissue homeostasis, morphogenesis, and tissue repair. However, remodeling could also be a part of many pathological states such as arthritis, cardiovascular diseases, neurodegenerative diseases, or impaired development in congenital anomalies. This book overviews the role of MMPs in different pathologies affecting the human body.

Metalloproteinases. --- Metalloproteases --- Metalloenzymes --- Proteinase --- Life Sciences --- Human Genetics --- Molecular Genetics --- Genetics and Molecular Biology --- Biochemistry